CERVICAL-CARCINOMA METASTATIC TO THE SKULL, HEART, AND LUNGS - ANALYSIS FOR HUMAN PAPILLOMAVIRUS DNA

被引:20
作者
YANUCK, MD
KAUFMAN, RH
WOODS, KV
ADLERSTORTHZ, K
机构
[1] UNIV TEXAS,HLTH SCI CTR,DEPT MICROBIOL,DENT BRANCH,POB 20068,HOUSTON,TX 77030
[2] UNIV TEXAS,BAYLOR COLL MED,DEPT OBSTET & GYNECOL,HOUSTON,TX 77030
[3] UNIV TEXAS,HLTH SCI CTR,GRAD SCH BIOMED SCI,HOUSTON,TX 77030
关键词
D O I
10.1016/0090-8258(91)90238-Z
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
In this case report we present a 21-year-old patient with stage IV cervical carcinoma metastatic to the skull at the time of diagnosis. The patient had two previous negative Pap smears performed 10 months and 15 months prior to the time of diagnosis. Postmortem examination 2 months following diagnosis showed cardiac and pulmonary metastases. Human papillomavirus (HPV) DNA was detected in the primary cervical tumor and skull metastasis, but absent in the cardiac and pulmonary metastases. This study details the first report in the medical literature of a skull metastasis present at the time of diagnosis of cervical carcinoma. It also represents the first report of HPV-negative metastases arising from an HPV-positive cervical cancer. © 1991.
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页码:94 / 97
页数:4
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