IMPROVING THE DELIVERY CAPACITY OF MICROPARTICLE SYSTEMS USING BLENDS OF POLY(DL-LACTIDE CO-GLYCOLIDE) AND POLY(ETHYLENE GLYCOL)

被引：52

作者：

YEH, MK ^{[1
]}

JENKINS, PG ^{[1
]}

DAVIS, SS ^{[1
]}

COOMBES, AGA ^{[1
]}

机构：

[1] UNIV NOTTINGHAM,DEPT PHARMACEUT SCI,NOTTINGHAM NG7 2RD,ENGLAND

来源：

JOURNAL OF CONTROLLED RELEASE | 1995年 / 37卷 / 1-2期

基金：

英国医学研究理事会;

关键词：

POLY(LACTIDE CO-GLYCOLIDE); POLY(ETHYLENE GLYCOL); BLENDS; PROTEIN; EMULSION; SOLVENT EXTRACTION; CONTROLLED-RELEASE; MICROPARTICLES; VACCINE;

D O I：

10.1016/0168-3659(95)00039-B

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The preparation of microparticles with an entrapped protein, ovalbumin (OVA), from blends of poly ( DL-lactide-co-glycolide) (PLG) and poly(ethyleneglycol) (PEG) using a water-in oil-in oil (w/o/o) emulsion/solvent extraction technique is described. Significant increases in protein loading levels to over 50% (w/w) have been achieved in microparticles larger than 10 mu m mean diameter and to over 25% (w/w) in small 2 mu m microparticles. Linear protein release profiles are exhibited by certain blend formulations in vitro over 30 days. The w/o/o formulation approach in combination with PLG/PEG blends shows potential for improving vaccine formulations and the delivery of hydrophilic drugs, therapeutic proteins and peptides.

引用

页码：1 / 9

页数：9

共 21 条

[1] DETERMINANTS OF RELEASE RATE OF TETANUS VACCINE FROM POLYESTER MICROSPHERES [J].

ALONSO, MJ ;

COHEN, S ;

PARK, TG ;

GUPTA, RK ;

SIBER, GR ;

LANGER, R .

PHARMACEUTICAL RESEARCH, 1993, 10 (07) :945-953

[2] THE BIODEGRADABILITY OF POLYESTER BLENDS [J].

CHA, Y ;

PITT, CG .

BIOMATERIALS, 1990, 11 (02) :108-112

[3] A ONE-WEEK SUBDERMAL DELIVERY SYSTEM FOR L-METHADONE BASED ON BIODEGRADABLE MICROCAPSULES [J].

CHA, Y ;

PITT, CG .

JOURNAL OF CONTROLLED RELEASE, 1988, 7 (01) :69-78

[4] CONTROLLED DELIVERY SYSTEMS FOR PROTEINS BASED ON POLY(LACTIC GLYCOLIC ACID) MICROSPHERES [J].

COHEN, S ;

YOSHIOKA, T ;

LUCARELLI, M ;

HWANG, LH ;

LANGER, R .

PHARMACEUTICAL RESEARCH, 1991, 8 (06) :713-720

[5]

COHN D, 1989, BIOMATERIALS, V10, P466

[6] GEL CASTING OF RESORBABLE POLYMERS .2. INVITRO DEGRADATION OF BONE-GRAFT SUBSTITUTES [J].

COOMBES, AGA ;

HECKMAN, JD .

BIOMATERIALS, 1992, 13 (05) :297-307

[7] SOLUTION TECHNIQUE TO INCORPORATE POLYETHYLENE OXIDE AND OTHER WATER-SOLUBLE POLYMERS INTO SURFACES OF POLYMERIC BIOMATERIALS [J].

DESAI, NP ;

HUBBELL, JA .

BIOMATERIALS, 1991, 12 (02) :144-153

[8]

EKMAN BM, 1986, Patent No. 213303

[9] CONTROLLED VACCINE RELEASE IN THE GUT-ASSOCIATED LYMPHOID-TISSUES .1. ORALLY-ADMINISTERED BIODEGRADABLE MICROSPHERES TARGET THE PEYERS PATCHES [J].

ELDRIDGE, JH ;

HAMMOND, CJ ;

MEULBROEK, JA ;

STAAS, JK ;

GILLEY, RM ;

TICE, TR .

JOURNAL OF CONTROLLED RELEASE, 1990, 11 (1-3) :205-214

[10] RELEASE OF HUMAN SERUM-ALBUMIN FROM POLY(LACTIDE-CO-GLYCOLIDE) MICROSPHERES [J].

HORA, MS ;

RANA, RK ;

NUNBERG, JH ;

TICE, TR ;

GILLEY, RM ;

HUDSON, ME .

PHARMACEUTICAL RESEARCH, 1990, 7 (11) :1190-1194

← 1 2 3 →