GABA RECEPTOR CONTROL OF PARASYMPATHETIC OUTFLOW TO HEART - CHARACTERIZATION AND BRAIN-STEM LOCALIZATION

被引：128

作者：

DIMICCO, JA

GALE, K

HAMILTON, B

GILLIS, RA

机构：

[1] GEORGETOWN UNIV,SCH DENT,DEPT PHARMACOL,WASHINGTON,DC 20007

[2] GEORGETOWN UNIV,SCH MED,DEPT ANAT,WASHINGTON,DC 20007

[3] GEORGETOWN UNIV,SCH DENT,DEPT ANAT,WASHINGTON,DC 20007

来源：

SCIENCE | 1979年 / 204卷 / 4397期

关键词：

D O I：

10.1126/science.451556

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Blockade of γ-aminobutyric acid (GABA) receptor function by direct microinjection of the GABA receptor antagonist bicuculline into the nucleus ambiguus of the brainstem produced a marked, dose-related depression of heart rate and blood pressure which was mediated by the vagus nerve. This effect was not obtained in other regions of the brainstem and was reversed by the GABA receptor agonist muscimol. These data indicate that the nucleus ambiguus may be the site of a GABA receptor-mediated inhibition of vagal outflow. Copyright © 1979 AAAS.

引用

页码：1106 / 1109

页数：4