ANTIVENOM AND BIOLOGICAL EFFECTS OF AR-TURMERONE ISOLATED FROM CURCUMA-LONGA (ZINGIBERACEAE)

被引：104

作者：

FERREIRA, LAF

HENRIQUES, OB

ANDREONI, AAS

VITAL, GRF

CAMPOS, MMC

HABERMEHL, GG

DEMORAES, VLG

机构：

[1] HOSP UNIV FED UBERLANDIA, UBERLANDIA, BRAZIL

[2] UNIV FED RIO DE JANEIRO, CTR CIENCIAS SAUDE, DEPT BIOQUIM, RIO DE JANEIRO, BRAZIL

[3] HANNOVER SCH VET MED, INST CHEM, W-3000 HANNOVER 1, GERMANY

来源：

TOXICON | 1992年 / 30卷 / 10期

关键词：

D O I：

10.1016/0041-0101(92)90437-A

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A potent antivenom against snakebite was isolated from Curcuma longa, a plant commonly used in traditional Brazilian medicine. The fraction consisting of ar-turmerone neutralized both the hemorrhagic activity present in Bothrops jararaca venom, and the lethal effect of Crotalus durissus terrificus venom in mice. Immunological studies demonstrated that this fraction also inhibited the proliferation and the natural killer activity of human lymphocytes.

引用

页码：1211 / 1218

页数：8

共 16 条

[11]

LIU Y, 1989, Patent No. 482859

[12] ISOLATION AND CHARACTERIZATION OF A PROTEOLYTIC-ENZYME FROM THE VENOM OF THE SNAKE BOTHROPS-JARARACA (JARARACA) [J].