STRUCTURAL AND FUNCTIONAL BASIS FOR HORMONE-BINDING AND RECEPTOR OLIGOMERIZATION

被引：94

作者：

WELLS, JA

机构：

[1] Department of Protein Engineering, Genentech, Inc, South Francisco, CA 94080

来源：

CURRENT OPINION IN CELL BIOLOGY | 1994年 / 6卷 / 02期

关键词：

D O I：

10.1016/0955-0674(94)90132-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Most single-pass transmembrane receptors undergo a change in oligomeric state upon hormone binding. Recent mutational, biophysical and structural studies of the human growth hormone and tumor necrosis factor receptor complexes have revealed much about the mechanisms and molecular bases for binding and oligomerization. Principles learned from these examples and others should apply to many other hormone-receptor complexes.

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页码：163 / 173

页数：11

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