STRUCTURAL AND FUNCTIONAL BASIS FOR HORMONE-BINDING AND RECEPTOR OLIGOMERIZATION

被引：94

作者：

WELLS, JA

机构：

[1] Department of Protein Engineering, Genentech, Inc, South Francisco, CA 94080

来源：

CURRENT OPINION IN CELL BIOLOGY | 1994年 / 6卷 / 02期

关键词：

D O I：

10.1016/0955-0674(94)90132-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Most single-pass transmembrane receptors undergo a change in oligomeric state upon hormone binding. Recent mutational, biophysical and structural studies of the human growth hormone and tumor necrosis factor receptor complexes have revealed much about the mechanisms and molecular bases for binding and oligomerization. Principles learned from these examples and others should apply to many other hormone-receptor complexes.

引用

页码：163 / 173

页数：11

共 65 条

[31]

ILONDO MM, 1994, IN PRESS ENDOCRINOLO

[32]

ISAKSSON OGP, 1985, ANNU REV PHYSIOL, V47, P483, DOI 10.1146/annurev.ph.47.030185.002411

[33] SIGNAL TRANSDUCTION MEDIATED BY GROWTH-HORMONE RECEPTOR AND ITS CHIMERIC MOLECULES WITH THE GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR [J].

ISHIZAKAIKEDA, E ;

FUKUNAGA, R ;

WOOD, WI ;

GOEDDEL, DV ;

NAGATA, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (01) :123-127

[34] THE POLYPEPTIDE ENCODED BY THE CDNA FOR HUMAN CELL-SURFACE ANTIGEN FAS CAN MEDIATE APOPTOSIS [J].

ITOH, N ;

YONEHARA, S ;

ISHII, A ;

YONEHARA, M ;

MIZUSHIMA, S ;

SAMESHIMA, M ;

HASE, A ;

SETO, Y ;

NAGATA, S .

CELL, 1991, 66 (02) :233-243

[35] STRUCTURE OF TUMOR NECROSIS FACTOR [J].

JONES, EY ;

STUART, DI ;

WALKER, NPC .

NATURE, 1989, 338 (6212) :225-228

[36]

KRUSE N, 1994, IN PRESS EMBO J

[37]

LEMON MA, 1992, J BIOL CHEM, V267, P7683

[38] GROWTH-HORMONE RECEPTOR AND SERUM BINDING-PROTEIN - PURIFICATION, CLONING AND EXPRESSION [J].

LEUNG, DW ;

SPENCER, SA ;

CACHIANES, G ;

HAMMONDS, RG ;

COLLINS, C ;

HENZEL, WJ ;

BARNARD, R ;

WATERS, MJ ;

WOOD, WI .

NATURE, 1987, 330 (6148) :537-543

[39]

LOETSCHER H, 1991, J BIOL CHEM, V266, P18324

[40]

LOETSCHER H, 1993, J BIOL CHEM, V268, P26350

← 1 2 3 4 5 6 7 →