AN INTRACISTERNAL A-PARTICLE SEQUENCE CODES FOR AN ANTIGEN RECOGNIZED BY SYNGENEIC CYTOLYTIC T-LYMPHOCYTES ON A MOUSE SPONTANEOUS LEUKEMIA

被引：34

作者：

DEBERGEYCK, V

DEPLAEN, E

CHOMEZ, P

BOON, T

VANPEL, A

机构：

[1] LUDWIG INST CANC RES, BRUSSELS BRANCH, B-1200 BRUSSELS, BELGIUM

[2] UNIV CATHOLIQUE LOUVAIN, CELLULAR GENET UNIT, B-1200 BRUSSELS, BELGIUM

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1994年 / 24卷 / 09期

关键词：

CYTOLYTIC T CELL EPITOPE; INTRACISTERNAL A PARTICLE; TUMOR ANTIGEN;

D O I：

10.1002/eji.1830240941

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cytolytic T lymphocyte (CTL) clones directed against spontaneous mouse leukemia LEC have been obtained. By transfecting a cosmid library into cells which were then tested for their ability to stimulate the CTL, we identified the gene coding for the antigen recognized by one of these CTL clones. It is the gag gene of an endogenous defective retrovirus that belongs to the intracisternal A particle (IAP) family. A gag-encoded nonapeptide presented by the H-2 D-k molecule caused recognition by the anti-LEC CTL clone. Southern blot and polymerase chain reaction analyses indicated that the expression of the antigen by the LEC tumor cell line resulted from the transposition of an IAP sequence into a new genomic location.

引用

页码：2203 / 2212

页数：10

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