FORMATION OF 8-HYDROXYDEOXYGUANOSINE (8-OH-DG) IN RAT-KIDNEY DNA AFTER INTRAPERITONEAL ADMINISTRATION OF FERRIC NITRILOTRIACETATE (FE-NTA)

被引：161

作者：

UMEMURA, T ^{[1
]}

SAI, K ^{[1
]}

TAKAGI, A ^{[1
]}

HASEGAWA, R ^{[1
]}

KUROKAWA, Y ^{[1
]}

机构：

[1] NATL INST HYG SCI,DIV TOXICOL,1-18-1 KAMIYOGA,SETAGAYA KU,TOKYO 158,JAPAN

来源：

CARCINOGENESIS | 1990年 / 11卷 / 02期

关键词：

D O I：

10.1093/carcin/11.2.345

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A significant increase of 8-hydroxydeoxyguanosine (8-OH-dG) was observed in the kidney DNA of rats given a renal carcinogen, the ferric complex of nitrilotriacetate (Fe-NTA) by single i.p. injection. By contrast, non- or weakly carcinogenic compounds, aluminum - nitrilotriacetate complex (A1-NTA), non-complexed NTA (Na2NTA) and ferric chloride had no effect on 8-OH-dG production in the kidney DNA. These results suggest the involvement of active oxygen radicals in Fe-NTA carcinogenesis. © 1990 Oxford University Press.

引用

页码：345 / 347

页数：3

共 19 条

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