PREPARATION AND EVALUATION OF SUSTAINED-RELEASE INDOMETHACIN NONPAREIL SEEDS

被引：5

作者：

ELMAHROUK, GM ^{[1
]}

ALMESHAL, MA ^{[1
]}

ALANGARY, AA ^{[1
]}

MAHROUS, GM ^{[1
]}

机构：

[1] KING SAUD UNIV,COLL PHARM,DEPT PHARMACEUT,POB 2457,RIYADH 11451,SAUDI ARABIA

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1993年 / 19卷 / 15期

关键词：

D O I：

10.3109/03639049309073897

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A controlled release oral drug delivery system of Indomethacin was developed using nonpareil seeds as a matrix system. These seeds were coated with different concentrations of drug release controlling materials viz Eudragit RL100 and Eudragit RS100, and bees wax. The particle size of the seeds and the concentration as well as the type of the drug release controlling Eudragits has a pronounced effect on the release rate profile of Indomethacin. All types of formulations showed release rate pattern which can be described by both first-order and diffusion controlled mechanism.

引用

页码：1903 / 1916

页数：14

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