CDC2 KINASE PHOSPHORYLATION OF DESMIN AT 3 SERINE THREONINE RESIDUES IN THE AMINO-TERMINAL HEAD DOMAIN

被引：32

作者：

KUSUBATA, M

MATSUOKA, Y

TSUJIMURA, K

ITO, H

ANDO, S

KAMIJO, M

YASUDA, H

OHBA, Y

OKUMURA, E

KISHIMOTO, T

INAGAKI, M

机构：

[1] TOKYO METROPOLITAN GERIATR HOSP & INST GERONTOL,DEPT NEUROPHYSIOL,35-2 SAKAE CHO,ITABASHI KU,TOKYO 173,JAPAN

[2] MIE UNIV,SCH MED,DEPT PATHOL,TSU,MIE 514,JAPAN

[3] NAGOYA CITY UNIV,FAC PHARMACEUT SCI,DEPT CHEM HYG & NUTR,MIZUHO KU,NAGOYA,AICHI 464,JAPAN

[4] AICHI CANC CTR,RES INST,BIOPHYS UNIT,CHIKUSA KU,NAGOYA,AICHI 464,JAPAN

[5] KANAZAWA UNIV,FAC PHARMACEUT SCI,DIV BIOL,KANAZAWA,ISHIKAWA 920,JAPAN

[6] TOKYO INST TECHNOL,FAC BIOSCI & BIOTECHNOL,CELL & DEV BIOL LAB,MIDORI KU,YOKOHAMA,KANAGAWA 227,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 190卷 / 03期

关键词：

D O I：

10.1006/bbrc.1993.1138

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phosphorylation of desmin filament by cdc2 kinase Induced a transition toward the depolymerized state of the filament. Sequence analysis of purified phosphopeptides derived from cdc2 kinase-phosphorylated desmin revealed that Ser-6, Ser-22 and Thr-64 in the N-terminal head domain were the sites phosphorylated. © 1993 Academic Press.

引用

页码：927 / 934

页数：8

共 24 条

[11] PHOSPHORYLATION INVITRO OF VIMENTIN BY PROTEIN KINASE-A AND KINASE-C IS RESTRICTED TO THE HEAD DOMAIN - IDENTIFICATION OF THE PHOSPHOSERINE SITES AND THEIR INFLUENCE ON FILAMENT FORMATION [J].

GEISLER, N ;

HATZFELD, M ;

WEBER, K .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1989, 183 (02) :441-447

[12] PHOSPHORYLATION OF DESMIN INVITRO INHIBITS FORMATION OF INTERMEDIATE FILAMENTS - IDENTIFICATION OF 3 KINASE-A SITES IN THE AMINOTERMINAL HEAD DOMAIN [J].

GEISLER, N ;

WEBER, K .

EMBO JOURNAL, 1988, 7 (01) :15-20

[13] TRANSFORMING GENE-PRODUCT OF ROUS-SARCOMA VIRUS PHOSPHORYLATES TYROSINE [J].

HUNTER, T ;

SEFTON, BM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (03) :1311-1315

[14]

INAGAKI M, 1990, J BIOL CHEM, V265, P4722

[15] SITE-SPECIFIC PHOSPHORYLATION INDUCES DISASSEMBLY OF VIMENTIN FILAMENTS INVITRO [J].

INAGAKI, M ;

NISHI, Y ;

NISHIZAWA, K ;

MATSUYAMA, M ;

SATO, C .

NATURE, 1987, 328 (6131) :649-652

[16]

INAGAKI M, 1988, J BIOL CHEM, V263, P5970

[17]

KITAMURA S, 1989, J BIOL CHEM, V264, P5674

[18]

KUSUBATA M, 1992, J BIOL CHEM, V267, P20937

[19] 2 DIFFERENT PROTEIN-KINASES ACT ON A DIFFERENT TIME SCHEDULE AS GLIAL FILAMENT KINASES DURING MITOSIS [J].

MATSUOKA, Y ;

NISHIZAWA, K ;

YANO, T ;

SHIBATA, M ;

ANDO, S ;

TAKAHASHI, T ;

INAGAKI, M .

EMBO JOURNAL, 1992, 11 (08) :2895-2902

[20] SEQUENCE-ANALYSIS OF PHOSPHOSERINE-CONTAINING PEPTIDES - MODIFICATION FOR PICOMOLAR SENSITIVITY [J].

MEYER, HE ;

HOFFMANNPOSORSKE, E ;

KORTE, H ;

HEILMEYER, LMG .

FEBS LETTERS, 1986, 204 (01) :61-66

← 1 2 3 →