DIASTEREOSELECTIVE ELECTROPHILIC AMINATION OF KETONE ENOLATES IN 2-SUBSTITUTED 2-ACYL-1,3-DITHIANE 1-OXIDES

被引：18

作者：

PAGE, PCB ^{[1
]}

ALLIN, SM ^{[1
]}

COLLINGTON, EW ^{[1
]}

CARR, RAE ^{[1
]}

机构：

[1] GLAXO GRP RES LTD,GREENFORD UB6 0HE,MIDDX,ENGLAND

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 15期

关键词：

D O I：

10.1016/0040-4039(94)85237-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enolate anions derived from 2-substituted 2-acyl-1,3-dithiane 1-oxides react readily with the nitrogen electrophile di-tert-butyl azodicarboxylate (DBAD) to give alpha-aminoketones with good diastereoselectivity and in reasonable yields; in some cases diastereoselectivity appears sufficiently high that the minor isomer cannot be detected by 400 MHz H-1 NMR spectroscopy.

引用

页码：2427 / 2430

页数：4