THE SYNTHESIS OF 6-ALPHA,7-BETA-DIHYDROXYVOUACAPAN-17-BETA-OIC ACID-DERIVATIVES .2. CARBAMATE AND AMINE DERIVATIVES

被引：10

作者：

MALTHA, CRA ^{[1
]}

STEFANI, GM ^{[1
]}

PILOVELOSO, D ^{[1
]}

机构：

[1] UNIV FED MINAS GERAIS,ICEX,DEPT QUIM,BELO HORIZONT,MG,BRAZIL

来源：

JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY | 1995年 / 6卷 / 04期

关键词：

6-ALPHA; 7-BETA-DIHYDROXYVOUACAPAN-17-BETA-OIC ACID; FURANE-DITERPENE; CARBAMATE; MOLECULAR REARRANGEMENT;

D O I：

10.5935/0103-5053.19950061

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The furane-diterpene 6 alpha,7 beta-dihydroxyvouacapan-17 beta-oic acid I (ADV), isolated from Pterodon polygalaeflorus Benth fruits presents both anti-inflammatory and analgesic activities. In order to gather data for pharmacological studies, new derivatives of ADV were obtained: urethane V and amine VI. Their structures were determined on the basis of IV, H-1-NMR, C-13-NMR and Mass spectrometric data.

引用

页码：357 / 360

页数：4

共 13 条

[1]

Allen C.F.H., 1963, ORG SYNTH COLL, V4, P45

[2]

BARTON D, 1979, COMP ORGANIC CHEM, V2

[3] STEREOSPECIFIC LOSSEN REARRANGEMENTS [J].

BAUER, L ;

MIARKA, SV .

JOURNAL OF ORGANIC CHEMISTRY, 1959, 24 (09) :1293-1296

[4] DITERPENOID FURANS FROM PTERODON SPECIES [J].

FASCIO, M ;

MORS, WB ;

GILBERT, B ;

MAHAJAN, JR ;

MONTEIRO, MB ;

DOSSANTOSFILHO, D ;

VICHNEWSKI, W .

PHYTOCHEMISTRY, 1976, 15 (01) :201-203

[5] NEW DITERPENOIDS FROM PTERODON-EMARGINATUS VOG [J].

MAHAJAN, JR ;

MONTEIRO, MB .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1973, (05) :520-525

[6]

MALTHA CRA, 1994, ESTUDO SINTESE AMINA

[7] CHEMOPROPHYLACTIC AGENT IN SCHISTOSOMIASIS - 14,15-EPOXYGERANYLGERANIOL [J].

MORS, WB ;

DOSSANTO.MF ;

MONTEIRO, HJ ;

GILBERT, B ;

PELLEGRINO, J .

SCIENCE, 1967, 157 (3791) :950-+

[8]

NUNAN EA, 1982, BRAZ J MED BIOL RES, V15, P450

[9] Synthesis of 6 alpha, 7 beta-di-hydroxyvouacapan-17 beta-oic acid Derivatives. Parte I: Hydroxamic Acid and Amide Derivatives [J].

Rubinger, Mayura M. M. ;

Veloso, Dorila Pilo ;

Stefani, Guglielmo Marconi ;

Alves, Dalton L. Ferreira .

JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, 1991, 2 (03) :124-128

[10]

SACRAMENTO TM, 1994, THESIS U FEDERAL MIN

← 1 2 →