EFFECT OF LEAD ON LIPID-PEROXIDATION IN LIVER OF RATS

被引：121

作者：

SANDHIR, R

GILL, KD

机构：

[1] POSTGRAD INST MED EDUC & RES,DEPT BIOCHEM,CHANDIGARH 160012,INDIA

[2] AVADH UNIV,DEPT BIOCHEM,FAIZABAD 224001,UTTAR PRADESH,INDIA

来源：

BIOLOGICAL TRACE ELEMENT RESEARCH | 1995年 / 48卷 / 01期

关键词：

LEAD; LIVER; LIPID PEROXIDATION; ANTIOXIDANT ENZYMES; GLUTATHIONE;

D O I：

10.1007/BF02789081

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The present study was undertaken to understand the biochemical mechanisms of lead toxicity in liver. We observed a significant accumulation of lead in liver following lead treatment, resulting in accentuation of lipid peroxidation. Concomitant to the increase in lipid peroxidation, the activities of antioxidant enzymes, viz., superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase, were significantly inhibited. A decrease in reduced glutathione with a simultaneous increase in oxidized glutathione was observed following lead exposure, resulting in a reduced GSH/GSSG ratio. These results indicate that lead exerts its toxic effects by enhancing peroxidative damage to the membranes, thus compromising cellular functions.

引用

页码：91 / 97

页数：7