REGIOSELECTIVE AND STEREOSELECTIVE SYNTHESIS OF BETA-HALOHYDRINS FROM 1,2-EPOXIDES WITH AMMONIUM HALIDES IN THE PRESENCE OF METAL-SALTS

被引：62

作者：

CHINI, M ^{[1
]}

CROTTI, P ^{[1
]}

GARDELLI, C ^{[1
]}

MACCHIA, F ^{[1
]}

机构：

[1] UNIV PISA,DIPARTIMENTO CHIM BIOORGAN,VIA BONANNO 33,I-56126 PISA,ITALY

来源：

TETRAHEDRON | 1992年 / 48卷 / 18期

关键词：

D O I：

10.1016/S0040-4020(01)92271-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple efficient, stereoselective, and regioselective method for the synthesis of beta-chlorohydrins, beta-bromohydrins, and beta-iodohydrins by the direct opening of 1,2-epoxides with the corresponding ammonium halide in acetonitrile, in the presence of metal salts. is described. This new method appears to be of general use and competitive with the other methods previously reported.

引用

页码：3805 / 3812

页数：8

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