THE EFFECTS OF 2,2',4,4',5,5'-HEXACHLOROBIPHENYL COTREATMENT ON THE DISPOSITION OF 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN IN MICE

被引：6

作者：

DEJONGH, J

DEVITO, M

DILIBERTO, J

VANDENBERG, M

BIRNBAUM, L

机构：

[1] US EPA, PHARMACOKINET BRANCH, RES TRIANGLE PK, NC 27711 USA

[2] UNIV UTRECHT, TOXICOL RES INST, 3508 TD UTRECHT, NETHERLANDS

[3] UNIV N CAROLINA, CTR ENVIRONM MED & LUNG BIOL, CHAPEL HILL, NC 27599 USA

来源：

TOXICOLOGY LETTERS | 1995年 / 80卷 / 1-3期

关键词：

2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN 2,2',4,4',5,5'-HEXACHLOROBIPHENYL; TOXICOKINETIC INTERACTIONS; HEPATIC CYP1A2 BINDING;

D O I：

10.1016/0378-4274(95)03387-Z

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Two groups of C57BL/6J mice received a single oral dose of 1 nmol/kg 2,3,7,8-[H-3]tetrachlorodibenzo-p-dioxin (TCDD) alone or in combination with 300 mu mol/kg 2,2',4,4',5,5 '-hexachlorobiphenyl (HxCB). The disposition of TCDD in liver, fat, skin, spleen, lung and blood was studied at days 3, 7, 13 and 34 after dosage. HxCB cotreatment increased hepatic TCDD levels and, consequently, significant increases of the liver/fat distribution ratio were observed. HxCB cotreatment did not significantly affect TCDD levels in fat or other tissues. The elimination rates of TCDD were not influenced by HxCB cotreatment in any of the tissues. It is concluded that HxCB cotreatment alters the body distribution of TCDD in mice but does not influence the elimination rate of TCDD.

引用

页码：131 / 137

页数：7

共 25 条

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