RESOLUTION AND COMPARATIVE ANTI-HIV EVALUATION OF THE ENANTIOMERS OF CALANOLIDE-A AND CALANOLIDE-B

被引：54

作者：

CARDELLINA, JH ^{[1
]}

BOKESCH, HR ^{[1
]}

MCKEE, TC ^{[1
]}

BOYD, MR ^{[1
]}

机构：

[1] NCI,DIV CANC TREATMENT,DRUG DISCOVERY RES & DEV LAB,DEV THERAPEUT PROGRAM,FREDERICK,MD 21702

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 09期

关键词：

D O I：

10.1016/0960-894X(95)00158-P

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Methods for the chiral resolution of (+)-calanolide A and (-)-calanolide A from synthetic (+/-)-calanolide A, and of (+)-calanolide B and (-)-calanolide B (costatolide) from a scalemic mixture isolated from C. lanigerium, have been developed. Calanolide A was originally isolated as the pure (+) enantiomer from C. lanigerum, but now is also shown to occur as a scalemic mixture in latex of C. teysmannii. Interestingly, (+)-calanolide A and (-)-calanolide B are potent HIV-1 inhibitors, while (-)-calanolide A and (+)-calanolide B are inactive against the virus.

引用

页码：1011 / 1014

页数：4

共 9 条

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