ENDRIN-INDUCED PRODUCTION OF NITRIC-OXIDE BY RAT PERITONEAL-MACROPHAGES

被引：12

作者：

AKUBUE, PI ^{[1
]}

STOHS, SJ ^{[1
]}

机构：

[1] CREIGHTON UNIV,SCH PHARM & ALLIED HLTH,2500 CALIF ST,OMAHA,NE 68178

来源：

TOXICOLOGY LETTERS | 1992年 / 62卷 / 2-3期

关键词：

ENDRIN; RAT; PERITONEAL MACROPHAGES; NITRIC OXIDE SECRETION; ELLAGIC ACID;

D O I：

10.1016/0378-4274(92)90035-I

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The effect of oral endrin administration to rats on the production of nitric oxide (NO) by peritoneal macrophages was investigated. Nitric oxide formation was measured as nitrite. Endrin (4.5 mg/kg) enhanced the secretion of NO by approx. 300%. The effect of endrin on NO formation was both dose- and time-dependent. Ellagic acid, which has been shown to be a potent antioxidant, inhibited the elevation of NO production induced by endrin. These results suggest that the toxicity of endrin may at least in part be due to the production of an oxidative stress.

引用

页码：311 / 316

页数：6

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