IS TCR-BETA EXPRESSION AN ESSENTIAL EVENT IN EARLY THYMOCYTE DEVELOPMENT

被引：24

作者：

PALMER, DB ^{[1
]}

HAYDAY, A ^{[1
]}

OWEN, MJ ^{[1
]}

机构：

[1] YALE UNIV,DEPT BIOL,NEW HAVEN,CT 06511

来源：

IMMUNOLOGY TODAY | 1993年 / 14卷 / 09期

关键词：

D O I：

10.1016/0167-5699(93)90249-K

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The evolution of a T cell through the thymus is characterized by several distinct morphological changes. The underlying mechanisms allowing a double negative thymocyte to mature to a double positive one expressing both CD4 and CD8 are still hazy. Here, Donald Palmer, Adrian Hayday and Michael Owen discuss the latest development in the field and data that underscore the crucial role of TCR components in the transition of double negative to double positive thymocytes.

引用

页码：460 / 462

页数：3

共 14 条

[1] INHIBITION OF T-CELL RECEPTOR BETA-CHAIN GENE REARRANGEMENT BY OVEREXPRESSION OF THE NONRECEPTOR PROTEIN TYROSINE KINASE-P56LCK
ANDERSON, SJ
ABRAHAM, KM
NAKAYAMA, T
SINGER, A
PERLMUTTER, RM
[J]. EMBO JOURNAL, 1992, 11 (13) : 4877 - 4886
[2] EMBRYONIC STEM-CELLS AND HOMOLOGOUS RECOMBINATION
FUNGLEUNG, WP
MAK, TW
[J]. CURRENT OPINION IN IMMUNOLOGY, 1992, 4 (02) : 189 - 194
[3] T-CELL DEPLETION IN TRANSGENIC MICE CARRYING A MUTANT-GENE FOR TCR-BETA
KRIMPENFORT, P
OSSENDORP, F
BORST, J
MELIEF, C
BERNS, A
[J]. NATURE, 1989, 341 (6244) : 742 - 746
[4] A DOMINANT-NEGATIVE TRANSGENE DEFINES A ROLE FOR P56LCK IN THYMOPOIESIS
LEVIN, SD
ANDERSON, SJ
FORBUSH, KA
PERLMUTTER, RM
[J]. EMBO JOURNAL, 1993, 12 (04) : 1671 - 1680
[5] REARRANGEMENT AND DIVERSITY OF T-CELL RECEPTOR BETA-CHAIN GENES IN THYMOCYTES - A CRITICAL ROLE FOR THE BETA-CHAIN IN DEVELOPMENT
MALLICK, CA
DUDLEY, EC
VINEY, JL
OWEN, MJ
HAYDAY, AC
[J]. CELL, 1993, 73 (03) : 513 - 519
[6] THE SURROGATE LIGHT CHAIN IN B-CELL DEVELOPMENT
MELCHERS, F
KARASUYAMA, H
HAASNER, D
BAUER, S
KUDO, A
SAKAGUCHI, N
JAMESON, B
ROLINK, A
[J]. IMMUNOLOGY TODAY, 1993, 14 (02): : 60 - 68
[7] MOMBAERTS P, 1992, NATURE, V360, P255
[8] INTERLEUKIN-2 RECEPTOR GAMMA CHAIN MUTATION RESULTS IN X-LINKED SEVERE COMBINED IMMUNODEFICIENCY IN HUMANS
NOGUCHI, M
YI, HF
ROSENBLATT, HM
FILIPOVICH, AH
ADELSTEIN, S
MODI, WS
MCBRIDE, OW
LEONARD, WJ
[J]. CELL, 1993, 73 (01) : 147 - 157
[9] OWEN JJT, 1988, IMMUNOLOGY, V63, P639
[10] LYMPHOID DEVELOPMENT IN MICE CONGENITALLY LACKING T-CELL RECEPTOR-ALPHA-BETA EXPRESSING CELLS
PHILPOTT, KL
VINEY, JL
KAY, G
RASTAN, S
GARDINER, EM
CHAE, S
HAYDAY, AC
OWEN, MJ
[J]. SCIENCE, 1992, 256 (5062) : 1448 - 1452

← 1 2 →