MECHANISM AND MANAGEMENT OF TREATMENT-RELATED GONADAL FAILURE IN RECIPIENTS OF HIGH-DOSE CHEMORADIOTHERAPY

被引:145
作者
APPERLEY, JF [1 ]
REDDY, N [1 ]
机构
[1] HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,DEPT OBSTET & GYNAECOL,LONDON W12 0NN,ENGLAND
关键词
D O I
10.1016/S0268-960X(95)90030-6
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
For the last two decades, the use of bone marrow transplantation for leukaemia, and most recently for lymphomas and other cancers, has increased dramatically and all of the systemic chemotherapy or radiotherapy used in these patients has a potential for causing infertility. This review describes the normal reproductive function of relevance to patients at risk of chemotherapy- or radiotherapy-induced infertility. The mechanism by which fertility may be affected by these agents is also described and therapeutic strategies for reducing or preventing these problems are outlined. The treatment of men and women who are infertile after chemotherapy or radiotherapy is addressed, as are the ethical and legal aspects of assisted fertilization.
引用
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页码:93 / 116
页数:24
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