RESPONSE OF 2 STRAINS OF L5178Y CELLS TO CIS-DICHLOROBIS(CYCLOPENTYLAMINE)PLATINUM(II) .1. CROSS-SENSITIVITY TO CIS-PAD AND UV-LIGHT

被引：91

作者：

SZUMIEL, I

机构：

来源：

CHEMICO-BIOLOGICAL INTERACTIONS | 1979年 / 24卷 / 01期

关键词：

D O I：

10.1016/0009-2797(79)90102-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The response to cis-dichlorobis(cyclopentylamine)platinum(II) (cis-PAD) an antitumour platinum complex, was studied in two strains of murine lymphoma L5178Y cross-sensitive to X-rays and UV light. Dose-survival relationship, DNA synthesis, formation of chromatid aberrations, progression through the cell cycle, and growth and viability changes after 1 h cis-PAD treatment at 37°C were examined and compared with the effects of X-rays and UV light. In both strains, cis-PAD caused immediate inhibition of progression through the cell cycle, reduced rate of DNA synthesis, delayed appearance of chromatid aberrations, and delayed death; however, there is a marked difference in sensitivity to cis-PAD between L5178Y-S strain Do approx. 5.8 μg/ml and L5178Y-R strain (D0) approx. 2.5 μg/ml. In both strains a close resemblance was found between dose-survival relationships after cis-PAD and UV light treatment, respectively. © 1979.

引用

页码：51 / 72

页数：22

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