SYNTHESIS OF A POTENT, REVERSIBLE INHIBITOR OF INTERLEUKIN-1-BETA CONVERTING ENZYME

被引:77
作者
CHAPMAN, KT
机构
[1] Department of Medicinal Chemical Research Merck Research Laboratories Rahway
关键词
D O I
10.1016/S0960-894X(01)81209-9
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
An efficient synthesis of L - 709,049, a potent inhibitor of Interleukin-1-beta converting enzyme (ICE) is reported. The aspartic acid aldehyde moiety is protected as the corresponding O-benzylacylal which can be conveniently coupled to AcTyrValAla and hydrogenolyzed to afford the desired product.
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页码:613 / 618
页数:6
相关论文
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