MANUMYCIN-E, MANUMYCIN-F AND MANUMYCIN-G, NEW MEMBERS OF MANUMYCIN CLASS ANTIBIOTICS, FROM STREPTOMYCES SP

被引：21

作者：

SHU, YZ ^{[1
]}

HUANG, S ^{[1
]}

WANG, RR ^{[1
]}

LAM, KS ^{[1
]}

KLOHR, SE ^{[1
]}

VOLK, KJ ^{[1
]}

PIRNIK, DM ^{[1
]}

WELLS, JS ^{[1
]}

FERNANDES, PB ^{[1
]}

PATEL, PS ^{[1
]}

机构：

[1] BRISTOL MYERS SQUIBB PHARMACEUT RES INST,PRINCETON,NJ 08543

来源：

JOURNAL OF ANTIBIOTICS | 1994年 / 47卷 / 03期

关键词：

D O I：

10.7164/antibiotics.47.324

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Three new manumycin class antibiotics, namely manumycins E, F and G, were isolated from the culture broth of Streptomyces sp. strain WB-8376. Their structures were established by spectroscopic methods, and the S configuration of C-4 in the epoxycyclohexenone moiety was determined by CD exciton chirality method for each of the three compounds. Manumycins E, F and G are active against Gram-positive bacteria, and have moderate inhibitory effects on the farnesylation of p21 ras protein. They demonstrated weak cytotoxic activity against human colon tumor cell HCT-116.

引用

页码：324 / 333

页数：10

共 21 条

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