AN INVESTIGATION OF (R)-(+)-1-(1-NAPHTHYL)ETHYLIMINES AND (R)-(+)-1-(PHENYL)ETHYLIMINES AS CHIRAL TEMPLATES IN THE STAUDINGER REACTION

被引:28
作者
GEORG, GI
WU, ZJ
机构
关键词
STAUDINGER REACTION; (R)-(+)-1-(1-NAPHTHYL)ETHYLAMINE; (R)-(+)-1-(PHENYL)ETHYLAMINE; CHIRAL TEMPLATE; ASYMMETRIC SYNTHESIS; BETA-LACTAMS; SOLVENT EFFECTS;
D O I
10.1016/0040-4039(94)85059-3
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
(R)-(+)-1-)1-Napthyl)ethylimines were found to be moderately better chiral templates in the Staudinger reaction in comparison to (R)-(+)-1-(phenyl)ethylimines. The best diastereoselectivities and yields were obtained with (R)-(+)-1-(1-napthyl)ethylimines when toluene was used as the solvent. The resulting diastereomeric cis beta-lactams were separated by silica gel flash column chromatography or recrystallization.
引用
收藏
页码:381 / 384
页数:4
相关论文
共 10 条