GLYCOSYLATION OF THE ACTIVE SEQUENCE SER-ILE-LYS-VAL-ALA-VAL FROM THE ALPHA-1 CHAIN OF LAMININ REDUCES TUMOR-CELL ATTACHMENT ACTIVITY

被引：4

作者：

BARCHI, JJ ^{[1
]}

RUSS, P ^{[1
]}

JOHNSON, B ^{[1
]}

OTAKA, A ^{[1
]}

NOMIZU, M ^{[1
]}

YAMADA, Y ^{[1
]}

机构：

[1] NIDR, DEV BIOL LAB, BETHESDA, MD 20892 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 07期

关键词：

D O I：

10.1016/0960-894X(95)00100-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

N-terminal serine O-glycopeptides of SIKVAV-, a sequence located on the long arm of the alpha 1 chain of laminin, were synthesized to study the effect of glycosylation on the adhesive properties of this biologically relevant peptide. The data show that covalently linked carbohydrates decrease the cell-attachment activity in a structurally dependent manner.

引用

页码：711 / 714

页数：4

共 18 条

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