GLYCOSYLATION OF THE ACTIVE SEQUENCE SER-ILE-LYS-VAL-ALA-VAL FROM THE ALPHA-1 CHAIN OF LAMININ REDUCES TUMOR-CELL ATTACHMENT ACTIVITY

被引：4

作者：

BARCHI, JJ ^{[1
]}

RUSS, P ^{[1
]}

JOHNSON, B ^{[1
]}

OTAKA, A ^{[1
]}

NOMIZU, M ^{[1
]}

YAMADA, Y ^{[1
]}

机构：

[1] NIDR, DEV BIOL LAB, BETHESDA, MD 20892 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 07期

关键词：

D O I：

10.1016/0960-894X(95)00100-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

N-terminal serine O-glycopeptides of SIKVAV-, a sequence located on the long arm of the alpha 1 chain of laminin, were synthesized to study the effect of glycosylation on the adhesive properties of this biologically relevant peptide. The data show that covalently linked carbohydrates decrease the cell-attachment activity in a structurally dependent manner.

引用

页码：711 / 714

页数：4

共 18 条

[11] LEUKOCYTE TRAFFIC TO SITES OF INFLAMMATION
JUTILA, MA
[J]. APMIS, 1992, 100 (03) : 191 - 201
[12] AZIDONITRATION OF TRI-O-ACETYL-D-GALACTAL
LEMIEUX, RU
RATCLIFFE, RM
[J]. CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1979, 57 (10): : 1244 - 1251
[13] LIOTTA LA, 1983, LAB INVEST, V49, P636
[14] NOMIZU M, 1992, J BIOL CHEM, V267, P14118
[15] Ogura H., 1992, CARBOHYDRATES SYNTHE
[16] SCHMIDT RR, 1987, STEREOCHEMISTRY ORGA, P169
[17] TASHIRO K, 1989, J BIOL CHEM, V264, P16174
[18] BIOLOGICAL ROLES OF OLIGOSACCHARIDES - ALL OF THE THEORIES ARE CORRECT
VARKI, A
[J]. GLYCOBIOLOGY, 1993, 3 (02) : 97 - 130

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