GLYCOSYLATION OF THE ACTIVE SEQUENCE SER-ILE-LYS-VAL-ALA-VAL FROM THE ALPHA-1 CHAIN OF LAMININ REDUCES TUMOR-CELL ATTACHMENT ACTIVITY

被引:4
作者
BARCHI, JJ [1 ]
RUSS, P [1 ]
JOHNSON, B [1 ]
OTAKA, A [1 ]
NOMIZU, M [1 ]
YAMADA, Y [1 ]
机构
[1] NIDR, DEV BIOL LAB, BETHESDA, MD 20892 USA
关键词
D O I
10.1016/0960-894X(95)00100-8
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
N-terminal serine O-glycopeptides of SIKVAV-, a sequence located on the long arm of the alpha 1 chain of laminin, were synthesized to study the effect of glycosylation on the adhesive properties of this biologically relevant peptide. The data show that covalently linked carbohydrates decrease the cell-attachment activity in a structurally dependent manner.
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收藏
页码:711 / 714
页数:4
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