EFFECTS OF MEFLOQUINE ON ESCHERICHIA-COLI

被引：20

作者：

BROWN, RE

STANCATO, FA

WOLFE, AD

机构：

[1] Department of Biological Chemistry, Division of Biochemistry, Walter Reed Army Institute of Research, Washington

来源：

LIFE SCIENCES | 1979年 / 25卷 / 21期

关键词：

D O I：

10.1016/0024-3205(79)90434-X

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Mefloquine, a quinoline-4-methanol antimalarial drug, also possesses bactericidal activity. Mefloquine causes rapid loss of bacterial viability, cell and spheroplast lysis, cessation of macromolecular synthesis, release of macromolecular constituents, and inhibition of the oxidation of NADH by isolated E. coli membranes. Results are consistent with the hypothesis that mefloquine is a membrane-active drug. © 1979.

引用

页码：1857 / 1864

页数：8

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