THE CONTROL OF CELLULAR MOTILITY AND THE ROLE OF GELSOLIN

被引：9

作者：

GRAZI, E

MAGRI, E

CUNEO, P

CATALDI, A

机构：

[1] Istituto di Chimica Biologica, Universitá di Ferrara, 44100 Ferrara

来源：

FEBS LETTERS | 1991年 / 295卷 / 1-3期

关键词：

GELSOLIN; CELL MOTILITY;

D O I：

10.1016/0014-5793(91)81409-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Solation of actin gel by gelsolin is much less efficient in the presence of a high concentration of macromolecular solutes. The rigidity of the gel formed by 12-mu-M actin is lowered from 4 to 0.33 dynes/cm2 by 15 nM gelsolin, while in 6% (w/v) polyethylene glycol, rigidity is lowered only from 20 to 11 dynes/cm2 by 64 nM gelsolin. Owing to the large concentration of protein, transitions in the fluid- and gel-like properties of the cytoplasm are expected to be problematic when promoted by gelsolin alone.

引用

页码：163 / 166

页数：4

共 16 条

[1] DIRECT ELECTRON-MICROSCOPIC VISUALIZATION OF BARBED END CAPPING AND FILAMENT CUTTING BY INTESTINAL MICROVILLAR 95-KDALTON PROTEIN (VILLIN) - A NEW ACTIN ASSEMBLY ASSAY USING THE LIMULUS ACROSOMAL PROCESS [J].