IMPACT OF POLYCHLORINATED DIBENZO-P-DIOXINS, DIBENZOFURANS, AND BIPHENYLS ON HUMAN AND ENVIRONMENTAL-HEALTH, WITH SPECIAL EMPHASIS ON APPLICATION OF THE TOXIC EQUIVALENCY FACTOR CONCEPT

被引：184

作者：

AHLBORG, UG

BROUWER, A

FINGERHUT, MA

JACOBSON, JL

JACOBSON, SW

KENNEDY, SW

KETTRUP, AAF

KOEMAN, JH

POIGER, H

RAPPE, C

SAFE, SH

SEEGAL, RF

TUOMISTO, J

VANDENBERG, M

机构：

[1] KAROLINSKA INST, INST ENVIRONM MED, S-10401 STOCKHOLM 60, SWEDEN

[2] AGR UNIV WAGENINGEN, DEPT TOXICOL, 6700 HB WAGENINGEN, NETHERLANDS

[3] NIOSH, CINCINNATI, OH 45226 USA

[4] WAYNE STATE UNIV, DEPT PSYCHOL, DETROIT, MI 48202 USA

[5] ENVIRONM CANADA, CANADIAN WILDLIFE SERV, HULL, PQ, CANADA

[6] GESELL STRAHLENFORSCH, INST OKOL, NEUHERBERG, GERMANY

[7] UNIV ZURICH, INST TOXICOL, CH-8603 SCHWERZENBACH, SWITZERLAND

[8] UMEA UNIV, INST ENVIRONM CHEM, S-90187 UMEA, SWEDEN

[9] TEXAS A&M UNIV SYST, DEPT VET PHYSIOL & PHARMACOL, COLL STN, TX 77843 USA

[10] NEW YORK STATE DEPT HLTH, WADSWORTH CTR, ALBANY, NY 12201 USA

[11] NATL PUBL HLTH INST, DIV ENVIRONM HLTH, KUOPIO, FINLAND

[12] UNIV UTRECHT, TOXICOL RES INST, UTRECHT, NETHERLANDS

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY-ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY SECTION | 1992年 / 228卷 / 04期

关键词：

POLYCHLORINATED DIBENZO-P-DIOXINS (PCDDS); POLYCHLORINATED DIBENZOFURANS (PCDFS); POLYCHLORINATED BIPHENYLS (PCBS); AH RECEPTORS; AH (ARYL-HYDROCARBON)-MEDIATED EFFECTS; NON-AH (ARYL-HYDROCARBON)-MEDIATED EFFECTS; TOXIC EQUIVALENCY FACTOR (TEF); RISK MANAGEMENT; NEUROBEHAVIORAL RESPONSES; CARCINOGENICITY; ENDOCRINE RESPONSES; KINETICS; METABOLISM; SPECIES DIFFERENCES;

D O I：

10.1016/0926-6917(92)90029-C

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A scientific evaluation was made of the mechanisms of action of polychlorinated dibenzo-p-dioxins, dibenzofurans and biphenyls. Distinction is made between the aryl-hydrocarbon (Ah) receptor-mediated and non-Ah receptor-mediated toxic responses. Special attention is paid to the applicability of the toxic equivalency factor (TEF) concept.

引用

页码：179 / 199

页数：21

共 185 条

[61] HELFERICH WG, 1991, MOL PHARMACOL, V40, P674
[62] EMBRYOTOXICITY, TERATOGENICITY, AND ARYL-HYDROCARBON HYDROXYLASE-ACTIVITY IN FORSTERS TERNS ON GREEN-BAY, LAKE-MICHIGAN
HOFFMAN, DJ
RATTNER, BA
SILEO, L
DOCHERTY, D
KUBIAK, TJ
[J]. ENVIRONMENTAL RESEARCH, 1987, 42 (01) : 176 - 184
[63] EFFECTS OF INUTERO EXPOSURE TO POLYCHLORINATED-BIPHENYLS AND RELATED CONTAMINANTS ON COGNITIVE-FUNCTIONING IN YOUNG-CHILDREN
JACOBSON, JL
JACOBSON, SW
HUMPHREY, HEB
[J]. JOURNAL OF PEDIATRICS, 1990, 116 (01) : 38 - 45
[64] EFFECTS OF EXPOSURE TO PCBS AND RELATED-COMPOUNDS ON GROWTH AND ACTIVITY IN CHILDREN
JACOBSON, JL
JACOBSON, SW
HUMPHREY, HEB
[J]. NEUROTOXICOLOGY AND TERATOLOGY, 1990, 12 (04) : 319 - 326
[65] EFFECTS OF PRENATAL PCB EXPOSURE ON COGNITIVE PROCESSING EFFICIENCY AND SUSTAINED ATTENTION
JACOBSON, JL
JACOBSON, SW
PADGETT, RJ
BRUMITT, GA
BILLINGS, RL
[J]. DEVELOPMENTAL PSYCHOLOGY, 1992, 28 (02) : 297 - 306
[66] JACOBSON SW, 1985, CHILD DEV, V56, P853, DOI 10.1111/j.1467-8624.1985.tb00158.x
[67] JACOBSON SW, 1985, ARCH TOXICOL, V62, P267
[68] Jensen AA, 1989, HALOGENATED BIPHENYL, P345
[69] Jirasek L, 1974, Cesk Dermatol, V49, P145
[70] CRITICAL-EVALUATION OF POLYCHLORINATED BIPHENYL TOXICITY IN TERRESTRIAL AND MARINE MAMMALS - INCREASING IMPACT OF NON-ORTHO AND MONO-ORTHO COPLANAR POLYCHLORINATED-BIPHENYLS FROM LAND TO OCEAN
KANNAN, N
TANABE, S
ONO, M
TATSUKAWA, R
[J]. ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, 1989, 18 (06) : 850 - 857

← 2 3 4 5 6 7 8 9 10 11 →