ALKYL ETHER DERIVATIVES OF THE FK-506 RELATED, IMMUNOSUPPRESSIVE MACROLIDE L-683,742 (C31-O-DESMETHYL ASCOMYCIN)

被引：8

作者：

GOULET, MT ^{[1
]}

HODKEY, DW ^{[1
]}

STARUCH, MJ ^{[1
]}

DUMONT, FJ ^{[1
]}

LIN, S ^{[1
]}

HUNG, SHY ^{[1
]}

SIEKIERKA, JJ ^{[1
]}

WYVRATT, MJ ^{[1
]}

机构：

[1] MERCK & CO INC,MERCK SHARP & DOHME RES LABS,DEPT IMMUNOL,RAHWAY,NJ 07065

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 07期

关键词：

D O I：

10.1016/S0960-894X(01)80265-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Ether derivatives of the FK-506 related macrolide L-683,742 (C31-O-desmethyl ascomycin) have been prepared by alkylation with various alkyl 2,2,2-trichloroacetimidates. The in vitro immunosuppressive activity of these analogs is dependent both on the size and site of attachment (C31-O vs. C32-O) of the ether group.

引用

页码：927 / 930

页数：4

共 14 条

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