ROUTINE REVERSED-PHASE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC MEASUREMENT OF URINARY VANILLYLMANDELIC ACID IN PATIENTS WITH NEURAL CREST TUMORS

被引：18

作者：

BERTANIDZIEDZIC, LM

KRSTULOVIC, AM

CIRIELLO, S

GITLOW, SE

机构：

[1] Catecholamine Research Laboratory, Department of Medicine, The Mount Sinai School of Medicine, New York

[2] Department of Chemistry, Manhattanville College, Purchase

[3] Catecholamine Research Laboratory, Department of Medicine, The Mount Sinai School of Medicine, New York

来源：

JOURNAL OF CHROMATOGRAPHY | 1979年 / 164卷 / 03期

关键词：

D O I：

10.1016/S0378-4347(00)81235-9

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A rapid and simple reversed-phase high-performance liquid chromatographic procedure for the determination of vanillylmandelic acid (VMA) is described. This method was applied in the determination of the VMA content in urine from normal subjects and patients with neural crest lesions. Sample preparation is minimal and the analysis is short (20 min) and reproducible. The sensitivity of the UV detection is in the ng range. By this technique, fourteen adult control subjects were found to excrete a mean of 2.86 μg VMA per mg creatinine, whereas twelve patients with pheochromocytoma excreted a mean of 15.7 μg VMA per mg creatinine. © 1979.

引用

页码：345 / 353

页数：9