PH DEPENDENT ALTERATIONS OF MONOEPOXIDES AND MONOCHLOROHYDRINS OF LINOLEIC-ACID, AND THEIR EXISTENCE IN-VIVO

被引：13

作者：

IWASE, H ^{[1
]}

TAKAHASHI, K ^{[1
]}

TAKATORI, T ^{[1
]}

SHIMIZU, T ^{[1
]}

AONO, K ^{[1
]}

YAMADA, Y ^{[1
]}

IWADATE, K ^{[1
]}

NAGAO, M ^{[1
]}

机构：

[1] UNIV TOKYO,FAC MED,DEPT BIOCHEM,BUNKYO KU,TOKYO 113,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 215卷 / 03期

关键词：

D O I：

10.1006/bbrc.1995.2555

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Some monoepoxides of linoleic acid (LA) were converted to monochlorohydrins in low-pH solutions containing chloride ions (Cl-). Conversely, monochlorohydrins of LA were converted to monoepoxides in high-pH solutions. We attempted to determine whether these monochlorohydrins and monoepoxides were produced from LA by the cytochrome-c-H2O2- and/or myeloperoxidase-H2O2-system. The existence of monoepoxides and monochlorohydrins of LA in leukocytes was confirmed by high-performance liquid chromatography (HPLC). Furthermore, leukotoxin in human leukemia cells (THP-1) was stained immunohistochemically by a monoclonal anti-leukotoxin antibody. (C) 1995 Academic, Press, Inc.

引用

页码：945 / 951

页数：7

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