USE OF GLUTARALDEHYDE-MODIFIED TIMOTHY GRASS-POLLEN EXTRACT IN NASAL HYPOSENSITIZATION TREATMENT OF HAY-FEVER

被引:41
作者
JOHANSSON, SGO
DEUSCHL, H
ZETTERSTROM, O
机构
[1] UNIV UPPSALA HOSP,DEPT LUNG MED,S-75014 UPPSALA,SWEDEN
[2] UNIV UPPSALA HOSP,DEPT OTORHINOLARYNGOL,S-75014 UPPSALA,SWEDEN
来源
INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY | 1979年 / 60卷 / 04期
关键词
D O I
10.1159/000232376
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
12 patients suffering from grass pollen hay fever were treated for 14 weeks pre- and co-seasonally by intranasal self-administration of an aqueous solution of a glutaraldehyde-treated timothy grass pollen allergen. These patients had a statistically significant decrease in nasal symptom scores during the grass pollen peak period and in nasal challenge end-point titre after the season compared to placebo-treated patients. No significant effect was seen on the eye symptoms. 1 patient withdrew from the trial as a consequence of too strong local nasal reactions during treatment. Most other patients treated with active material reported mild local reactions during the first minutes after administration of the nasal spray. In the actively treated group a significant increase in serum and nasal secretion of grass pollen specific IgE, IgG and IgA antibodies was obtained during the treatment. In contrast, in the placebo group a significant increase in IgE antibody levels in serum and secretion occurred during the pollen season. The reduction in symptoms and increase in antibody production together with the simplicity of the procedure makes this approach to immunotherapy attractive.
引用
收藏
页码:447 / 460
页数:14
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