FURTHER ULTRASTRUCTURAL EVIDENCE THAT SPIROCHETES MAY PLAY A ROLE IN THE ETIOLOGY OF ALZHEIMERS-DISEASE

被引：39

作者：

MIKLOSSY, J

KASAS, S

JANZER, RC

ARDIZZONI, F

VANDERLOOS, H

机构：

[1] UNIV FRIBOURG,FAC SCI,INST HISTOL & GEN EMBRYOL,CH-1700 FRIBOURG,SWITZERLAND

[2] UNIV LAUSANNE,CTR MICROSCOPIE ELECTR,CH-1005 LAUSANNE,SWITZERLAND

[3] UNIV LAUSANNE,INST ANAT,CH-1005 LAUSANNE,SWITZERLAND

来源：

NEUROREPORT | 1994年 / 5卷 / 10期

关键词：

ALZHEIMERS DISEASE; ATOMIC FORCE MICROSCOPE; AXIAL FILAMENT; PERIPLASMIC FIBRIL; SCANNING ELECTRON MICROSCOPE; SPIROCHETES;

D O I：

10.1097/00001756-199406020-00010

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

RECENTLY it was reported that, at autopsy, in neuropathologically confirmed cases of Alzheimer's disease spirochaetes were found in blood and cerebrospinal fluid using dark-field microscopy. Moreover, the spirochaetes were isolated and cultured from brain tissue. We now show, using scanning electron microscopy and atomic force microscopy that the helically shaped microorganisms isolated and cultured from the Alzheimer brains possess axial filaments. This indicates that these microorganisms taxonomically indeed belong to the order Spirochaetales. A morphometric analysis reinforces this notion.

引用

页码：1201 / 1204

页数：4

共 6 条

[1] ATOMIC FORCE MICROSCOPE [J].