A NEW PROCEDURE FOR CONSTRUCTION OF 2,6-TRANS-DISUBSTITUTED PIPERIDINES USING OSMIUM-CATALYZED ASYMMETRIC DIHYDROXYLATION - APPLICATION TO THE SYNTHESIS OF (+)-EPIDIHYDROPINIDINE AND (+)-SOLENOPSIN-A
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作者:
TAKAHATA, H
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机构:Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Toyama, 930-01
TAKAHATA, H
INOSE, K
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机构:Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Toyama, 930-01
INOSE, K
ARAYA, N
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机构:Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Toyama, 930-01
ARAYA, N
MOMOSE, T
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机构:Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Toyama, 930-01
MOMOSE, T
机构:
[1] Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Toyama, 930-01
An asymmetric synthesis of (+)-epidihydropinidine (1) and (+)-solenopsin A (2) has been achieved by starting with the Sharpless asymmetric dihydroxylation of the alpha-amino acid-derived N-alkenylurethanes (3) followed by subsequent aminocyclization.