3 GENES THAT ESCAPE X-CHROMOSOME INACTIVATION ARE CLUSTERED WITH A 6-MB YAC-CONTIG AND STS MAP IN XP11.21-P11.22

被引：63

作者：

MILLER, AP

GUSTASHAW, K

WOLFF, DJ

RIDER, SH

MONACO, AP

EBLE, B

SCHLESSINGER, D

GORSKI, JL

VANOMMEN, GJ

WEISSENBACH, J

WILLARD, HF

机构：

[1] CASE WESTERN RESERVE UNIV, SCH MED, DEPT GENET, CLEVELAND, OH 44106 USA

[2] CASE WESTERN RESERVE UNIV, SCH MED, CTR HUMAN GENET, CLEVELAND, OH 44106 USA

[3] STANFORD UNIV, DEPT GENET, STANFORD, CA 94306 USA

[4] JOHN RADCLIFFE HOSP, INST MOLEC MED, IMPERIAL CANC RES FUND LABS, OXFORD OX3 9DU, ENGLAND

[5] WASHINGTON UNIV, SCH MED, DEPT MOLEC MICROBIOL, ST LOUIS, MO 63110 USA

[6] UNIV MICHIGAN, DEPT PEDIAT, ANN ARBOR, MI 48109 USA

[7] LEIDEN UNIV, DEPT GENET, LEIDEN, NETHERLANDS

[8] INST PASTEUR, PARIS, FRANCE

[9] GENETHON SA, PARIS, FRANCE

[10] UNIV MICHIGAN, DEPT HUMAN GENET, ANN ARBOR, MI 48109 USA

来源：

HUMAN MOLECULAR GENETICS | 1995年 / 4卷 / 04期

关键词：

D O I：

10.1093/hmg/4.4.731

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In order to study the distribution of genes that escape X chromosome inactivation, a high density yeast artificial chromosome (YAC) contig and STS map spanning approximately 6 Mb has been constructed in Xp11.21-p11.22. The contig contains 113 YACs mapped with 53 markers, including 10 genes. Four genes have been assayed for their expression status on both the active and inactive human X chromosomes, and these data have been combined with previous results on two other genes in the contig. Three of these genes escape X inactivation and have been localized to a single YAC clone of similar to 1075 kb. The other three genes are subject to inactivation, with two of them lying among the genes that escape inactivation. These results suggest that there are both regional control signals as well as gene-specific elements that determine the X inactivation status of genes on the proximal short arm of the human X chromosome.

引用

页码：731 / 739

页数：9

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