EFFECTS OF HYALURODINASE UPON TUMOR FORMATION IN BALB-C MICE PAINTED WITH 7, 12-DIMETHYLBENZ-(A)ANTHRACENE

被引:22
作者
PAWLOWSKI, A
HABERMAN, HF
MENON, IA
机构
[1] Clinical Science Division, Dermatology Section, University of Toronto, Toronto, Ontario, M5S 1A8, Medical Sciences Building
关键词
D O I
10.1002/ijc.2910230118
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Experiments were performed to investigate the effects of hyaluronidase on chemical carcinogenesis. Two experiments were carried out using BALB/c mice. In the first experiment the mice were divided into three groups, viz. (1) painted with 7, 12‐dimethyl‐benz(a)anthracene (DMBA), (2) injected with hyaluronidase and painted with DMBA and (3) injected with saline and painted with DMBA. In the second experiment the mice were divided into three groups: (1) painted with DMBA, (2) injected with hyaluronidase and painted with DMBA and (3) injected with heat‐inactivated hyaluronidase and painted with DMBA. The tumor incidence and size of tumors were significantly lower in the group treated with hyaluronidase than in the other groups. The latent period was increased. The mitotic index of the skin adjacent to the tumors at the end of the experiment was decreased. These studies show that hyaluronidase can act as an anticarcinogenic agent. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company
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页码:105 / 109
页数:5
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