PHARMACOKINETICS OF PROPOFOL IN CHILDREN

被引:55
作者
JONES, RDM
CHAN, K
ANDREW, LJ
机构
[1] CHINESE UNIV HONG KONG,DEPT PHARMACOL,SHA TIN,HONG KONG
[2] UNIV HONG KONG,DEPT ANAESTHESIOL,HONG KONG,HONG KONG
关键词
Anaesthesia: paediatric; Anaesthetics; intravenous:; propofol; Pharmacokinetics:; children;
D O I
10.1093/bja/65.5.661
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
The pharmacokinetics of propofol were studied in 12 healthy Chinese children, aged 4-12 yr, undergoing circumcision under inhalation an-aesthesia. All patients received a single i.v. bolus dose of propofol 2.5 mg kg-1 and blood concentrations of propofol over the subsequent 24 h were measured using high pressure liquid chromatography with fluorimetric detection. Data were consistent with a three-compartment model with a mean (SEM) elimination half-life of 209 (29) min and total body clearance of 40.4 (3.6) ml min-1 kg-1. The mean (SEM) apparent volume of distribution at steady state was 5.0 (2.7) litre kg-1 and volume of the central compartment was 0.6 (0.1) litre kg-1. The mean (SEM) ratio of k12: k21 was 1.4 (0.2), suggesting that, after injection of a single bolus dose in children, propofol is distributed rapidly to the shallow compartment. The mean ratio of k31: k10 suggests that lipophilicity constrains return of the drug to the central compartment. © 1990 British Journal of Anaesthesia.
引用
收藏
页码:661 / 667
页数:7
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