A CRITICAL ROLE OF LAMBDA-5 PROTEIN IN B-CELL DEVELOPMENT

被引:541
作者
KITAMURA, D
KUDO, A
SCHAAL, S
MULLER, W
MELCHERS, F
RAJEWSKY, K
机构
[1] UNIV COLOGNE, INST GENET, W-5000 COLOGNE 41, GERMANY
[2] BASEL INST IMMUNOL, CH-4058 BASEL, SWITZERLAND
关键词
D O I
10.1016/0092-8674(92)90293-L
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The lambda-5 gene is a homolog of immunoglobulin J(lambda)-C(lambda) genes, expressed specifically in immature B-lineage cells. Lambda-5-encoded molecules form membrane complexes with mu or D(mu) proteins in association with an additional protein specifically expressed in immature B cells that is encoded by the V(pre-B) gene. We have generated mice in which the lambda-5 gene is inactivated by targeted gene disruption in embryonic stem cells. In these mice, B cell development in the bone marrow is blocked at the pre-B cell stage. However, the blockade is leaky, allowing B cells to populate the peripheral immune system at a low rate. These cells are allelically excluded and able to respond to antigen.
引用
收藏
页码:823 / 831
页数:9
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