TRANSCRIPTIONAL CONTROL BY THE RETINOBLASTOMA PROTEIN

被引：61

作者：

KOUZARIDES, T ^{[1
]}

机构：

[1] UNIV CAMBRIDGE,DEPT PATHOL,CAMBRIDGE,ENGLAND

来源：

SEMINARS IN CANCER BIOLOGY | 1995年 / 6卷 / 02期

基金：

英国惠康基金;

关键词：

RETINOBLASTOMA; TRANSCRIPTION;

D O I：

10.1006/scbi.1995.0012

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The retinoblastoma gene product is an abundant nuclear protein, whose 'pocket domain' mediates numerous protein-protein, interactions. A substantial proportion of the RB-interacting proteins are transcription factors suggesting that RB plays a fundamental role in the regulation of transcription. Via these interactions, RB can influence both the progression through the cell cycle and the expression of lineage specific products. In this review I discuss some of the likely mechanisms by which RB regulates cell proliferation and differentiation.

引用

页码：91 / 98

页数：8

共 59 条

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