CENTRAL MOTOR CONDUCTION TO HAND AND LEG MUSCLES IN HUNTINGTONS-DISEASE

被引:23
作者
HOMBERG, V
LANGE, HW
机构
[1] Neurological Therapy Center, Department of Neurology, Heinrich Heine University, Dusseldorf
[2] Department of Psychiatry, Heinrich Heine University, Dusseldorf
关键词
Corticospinal tract; Electromagnetic stimulation; Huntington's disease;
D O I
10.1002/mds.870050305
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Using electromagnetic stimulation of motor cortex and cervical or lumbar roots, central conduction times to the thenar and abductor hallucis muscles bilaterally were determined in a population of 32 patients with definite Huntington's disease (HD) and 14 subjects at risk. The HD patients showed a wide variety of different severity of choreatic movements, disease duration, and total disability. None of the stimulation parameters (latency after cortical stimulation, amplitude, threshold, or central conduction time) revealed statistically significant abnormalities compared with a normal control group as well as between patient subgroups. The data indicate that central motor conduction to upper and lower extremity muscles remains normal in Huntington's disease irrespective of the severity of the disorder. Copyright © 1990 Movement Disorder Society
引用
收藏
页码:214 / 218
页数:5
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共 28 条
  • [11] Cowan JMA, Dick SPR, Day BL, Rothwell JC, Thompson PD, Marsden CD, Abnormalities in central motor pathway in multiple sclerosis, Lancet, 2, pp. 304-307, (1984)
  • [12] Hess CW, Mills KR, Murray MF, Schriefer TN, Magnetic brain stimulation: central motor conduction studies in multiple sclerosis, Ann Neurol, 22, pp. 744-752, (1987)
  • [13] Ingram DA, Swash M, Central motor conduction is, abnormal in motor neurone disease, J Neurol Neurosurg Psychiatry, 50, pp. 159-166, (1987)
  • [14] Thompson PD, Dick JPR, Asselman P, Et al., Examination of motor function in lesions of the spinal cord by stimulation of the motor cortex, Ann Neurol, 21, pp. 389-396, (1987)
  • [15] Berardelli A, Inghilleri M, Manfredi M, Zamponi A, Cecconi V, Dolce G, Cortical and cervical stimulation after hemispheric infarction, J Neurol Neurosurg Psychiatry, 50, pp. 861-865, (1987)
  • [16] Dick JPR, Cowan JMA, Day BL, Et al., The corticomotoneurone connection is normal in Parkinson's disease, Nature, 310, pp. 407-409, (1985)
  • [17] Muller K, Homberg V, Lenard HG, Motor control in childhood onset dopa responsive dystonia (Segawa syndrome), Neuropediatrics, 20, pp. 185-191, (1990)
  • [18] Thompson PD, Dick JPR, Day BL, Et al., Electrophysiology of the corticomotoneurone pathways in patients with movement disorders, Movement Disorders, pp. 113-118, (1986)
  • [19] Berardelli A, Inghilleri M, Priori A, Accornero A, Manfredi M, Electrical stimulation of motor cortex in patients with motor disturbances, Non‐invasive Stimulation of Brain and Spinal Cord: Fundamentals and Clinical Applications, pp. 219-230, (1988)
  • [20] Caramia MD, Zarola F, Spadaro M, Pardal AM, Bernardi G, Neurophysiologic testing of the central impulse propagation characteristics in patients with sensorimotor disorders, Non‐invasive Stimulation of Brain and Spinal Cord: Fundamentals and Clinical Applications, pp. 193-206, (1988)