INTRODUCTION OF A LIPOPHILIC THIOETHER TETHER IN THE MINOR-GROOVE OF NUCLEIC-ACIDS FOR ANTISENSE APPLICATIONS

被引：27

作者：

MANOHARAN, M

JOHNSON, LK

TIVEL, KL

SPRINGER, RH

COOK, PD

机构：

[1] Department of Medicinal Chemistry, Isis Pharmaceuticals, Carlsbad, CA 92008

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(01)80760-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A 2'-O-hexylthiotrityl adenosine phosphoramidite has been synthesized and incorporated into oligonucleotide phosphodiesters and phosphorothioates. This tether has potential antisense applications, offers a convenient nucleophile for conjugation of various moieties that would reside in the minor groove, and may form novel tertiary structures.

引用

页码：2765 / 2770

页数：6

共 33 条

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