IMMUNOGLOBULIN SUBCLASS DISTRIBUTION AND BINDING CHARACTERISTICS OF ANTI-GQ1B ANTIBODIES IN MILLER-FISHER-SYNDROME

被引:97
作者
WILLISON, HJ
VEITCH, J
机构
[1] University of Glasgow, Department of Neurology, Institute of Neurological Sciences, Glasgow
关键词
MILER FISHER SYNDROME; GUILLAIN-BARRE SYNDROME; IMMUNOGLOBULIN SUBCLASSES; GQ1B GANGLIOSIDE; GM1; GANGLIOSIDE; AUTOANTIBODIES;
D O I
10.1016/0165-5728(94)90042-6
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Circulating IgG antibodies to carbohydrate determinants on GQ1b ganglioside are found in the acute phase sera of patients with Miller Fisher syndrome, a variant of Guillain-Barre syndrome. Here we report that the IgG subclass distribution of the anti-GQ1b antibodies is mainly restricted to IgG1 and IgG3 antibodies; subclasses typically associated with a T cell-dependent immune reponse to protein antigens. This is highly unusual in that IgG responses to carbohydrate determinants are typically of the IgG2 subclass. Anti-GQ1b antibodies also have a limited ability to bind GQ1b in a membrane-like environment, particularly at body temperature. These data suggest that the antigen initiating the immune response in MFS is not likely GQ1b but an unidentified cross-reactive glycoprotein antigen(s). Similar results were obtained for anti-GM1 IgG antibodies in Guillain-Barre syndrome.
引用
收藏
页码:159 / 165
页数:7
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