A NOVEL SYNTHESIS OF XANTHINES - SUPPORT FOR A NEW BINDING MODE FOR XANTHINES WITH RESPECT TO ADENOSINE AT ADENOSINE RECEPTORS

被引：60

作者：

PEET, NP

LENTZ, NL

MENG, EC

DUDLEY, MW

OGDEN, AML

DEMETER, DA

WEINTRAUB, HJR

BEY, P

机构：

[1] Merrell Dow Research Institute, Cincinnati, Ohio 45215

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1990年 / 33卷 / 12期

关键词：

D O I：

10.1021/jm00174a004

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：3127 / 3130

页数：4

共 33 条

[11] STRUCTURE-ACTIVITY-RELATIONSHIPS FOR N6-SUBSTITUTED ADENOSINES AT A BRAIN ADENOSINE-A1-RECEPTOR WITH A COMPARISON TO AN ADENOSINE-A2 RECEPTOR REGULATING CORONARY BLOOD-FLOW [J].

DALY, JW ;

PADGETT, W ;

THOMPSON, RD ;

KUSACHI, S ;

BUGNI, WJ ;

OLSSON, RA .

BIOCHEMICAL PHARMACOLOGY, 1986, 35 (15) :2467-2481

[12]

DALY JW, 1985, ADV CYCLIC NUCL PROT, V19, P29

[13] 1,3-DIALKYL-8-(PARA-SULFOPHENYL)XANTHINES - POTENT WATER-SOLUBLE ANTAGONISTS FOR A1-ADENOSINE AND A2-ADENOSINE RECEPTORS [J].

DALY, JW ;

PADGETT, W ;

SHAMIM, MT ;

BUTTSLAMB, P ;

WATERS, J .

JOURNAL OF MEDICINAL CHEMISTRY, 1985, 28 (04) :487-492

[14] GROUND-STATES OF MOLECULES .39. MNDO RESULTS FOR MOLECULES CONTAINING HYDROGEN, CARBON, NITROGEN, AND OXYGEN [J].

DEWAR, MJS ;

THIEL, W .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1977, 99 (15) :4907-4917

[15] GROUND-STATES OF MOLECULES .38. MNDO METHOD - APPROXIMATIONS AND PARAMETERS [J].

DEWAR, MJS ;

THIEL, W .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1977, 99 (15) :4899-4907

[16] THE DEVELOPMENT AND USE OF QUANTUM-MECHANICAL MOLECULAR-MODELS .76. AM1 - A NEW GENERAL-PURPOSE QUANTUM-MECHANICAL MOLECULAR-MODEL [J].

DEWAR, MJS ;

ZOEBISCH, EG ;

HEALY, EF ;

STEWART, JJP .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1985, 107 (13) :3902-3909

[17] A COMPUTATIONAL-PROCEDURE FOR DETERMINING ENERGETICALLY FAVORABLE BINDING-SITES ON BIOLOGICALLY IMPORTANT MACROMOLECULES [J].

GOODFORD, PJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1985, 28 (07) :849-857

[18]

GOODMAN RR, 1982, MOL PHARMACOL, V21, P329

[19] SYNTHESIS OF XANTHINES AS ADENOSINE ANTAGONISTS, A PRACTICAL QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP APPLICATION [J].

HAMILTON, HW ;

ORTWINE, DF ;

WORTH, DF ;

BADGER, EW ;

BRISTOL, JA ;

BRUNS, RF ;

HALEEN, SJ ;

STEFFEN, RP .

JOURNAL OF MEDICINAL CHEMISTRY, 1985, 28 (08) :1071-1079

[20] SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF PYRAZOLO[4,3-D]PYRIMIDIN-7-ONES AS ADENOSINE RECEPTOR ANTAGONISTS [J].

HAMILTON, HW ;

ORTWINE, DF ;

WORTH, DF ;

BRISTOL, JA .

JOURNAL OF MEDICINAL CHEMISTRY, 1987, 30 (01) :91-96

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