SYNTHESIS OF ANTITUMOR CARBON-BRIDGED IMIDAZOPYRIDAZINE CARBAMATES

被引：7

作者：

DENYER, CV

REDDY, MT

JENKINS, DC

RAPSON, E

WATTS, SDM

机构：

[1] WELLCOME RES LABS,DEPT MOLEC SCI,BECKENHAM BR3 3BS,KENT,ENGLAND

[2] WELLCOME RES LABS,DEPT BIOCHEM SCI,BECKENHAM BR3 3BS,KENT,ENGLAND

来源：

ARCHIV DER PHARMAZIE | 1994年 / 327卷 / 02期

关键词：

D O I：

10.1002/ardp.19943270207

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two carbon-bridged analogues 11 and 15 of the potent microtubule inhibitor BW1069C85 (1) have been synthesised and evaluated for antitubulin and antitumour activity in vitro. Though the compounds were somewhat less potent than BW1069C85, significant activity against tubulin polymerisation and cell proliferation was demonstrated in the assays.

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页码：95 / 98

页数：4

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