SYNTHESIS AND BIOLOGICAL PROPERTIES OF 1069C - A NEW SYNTHETIC ANTITUMOR AGENT WITH VERY LOW CROSS-RESISTANCE POTENTIAL

被引：6

作者：

HODGSON, ST ^{[1
]}

JENKINS, DC ^{[1
]}

KNICK, V ^{[1
]}

RAPSON, E ^{[1
]}

WATTS, SDM ^{[1
]}

机构：

[1] BURROUGHS WELLCOME CO,RES TRIANGLE PK,NC 27709

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 10期

关键词：

D O I：

10.1016/S0960-894X(00)80225-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel imidazopyridazine carbamate, 1069C, is a potent microtubule inhibitor which binds at the Colchicine site on tubulin and is effective in vivo against murine tumours made resistant to clinically used antitumour drugs.

引用

页码：1257 / 1262

页数：6

共 21 条

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