D-ALPHA-TOCOPHEROL CONTROL OF CELL-PROLIFERATION

被引：59

作者：

AZZI, A ^{[1
]}

BOSCOBOINIK, D ^{[1
]}

CHATELAIN, E ^{[1
]}

OZER, NK ^{[1
]}

STAUBLE, B ^{[1
]}

机构：

[1] UNIV BERN, INST BIOCHEM & MOLEK BIOL, CH-3012 BERN, SWITZERLAND

来源：

MOLECULAR ASPECTS OF MEDICINE | 1993年 / 14卷 / 03期

关键词：

D O I：

10.1016/0098-2997(93)90014-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Uncontrolled cell growth is at the basis of neoplastic proliferation and arteriosclerotic lesions. In vitro proliferation of vascular smooth muscle cells, Balb c/3T3 fibroblasts, retinal neuroepithelial cells and neuroblastoma cells is inhibited by d-alpha-tocopherol. On the contrary Chinese hamster ovary cells, osteosarcoma cells and macrophages are not sensitive. PDGF-BB activated proliferation is highly d-alpha-tocopherol sensitive while lysophosphatidic acid induced growth is poorly inhibited. d-beta-Tocopherol, an analogue of d-alpha-tocopherol, with similar antioxidant properties, does not inhibit proliferation. Protein kinase C activity is inhibited by d-alpha-tocopherol but not by d-beta-tocopherol, suggesting a central role of this enzyme in the control of cell proliferation by d-alpha-tocopherol. Activation of the transcription activation complex AP-1 (but not NFkappaB) is prevented by d-alpha-tocopherol and not by d-beta-tocopherol.

引用

页码：265 / 271

页数：7

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