Innate Immunity SNPs are Associated with Risk for Severe Sepsis after Burn Injury

被引：69

作者：

Barber, Robert C. ^{[1
]}

Chang, Ling-Yu E. ^{[1
]}

Arnoldo, Brett D. ^{[1
]}

Purdue, Gary F. ^{[1
]}

Hunt, John L. ^{[1
]}

Horton, Jureta W. ^{[1
]}

Aragaki, Corinne C. ^{[2
]}

机构：

[1] Univ Texas Southwestern Med Ctr Dallas, Dept Surg, 5323 Harry Hines Blvd, Dallas, TX 75390 USA

[2] Univ Texas Houston, Sch Publ Hlth, Div Epidemiol & Biostat, Houston, TX USA

来源：

CLINICAL MEDICINE & RESEARCH | 2006年 / 4卷 / 04期

关键词：

Allelic association; Burns; CD14; IL-6; Polymorphism; Sepsis; SNP; TLR4; TNF-alpha;

D O I：

10.3121/cmr.4.4.250

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: To analyze allelic association with clinical outcome in a cohort of burn patients. Patients: Two hundred twenty-eight individuals with burns >= 15% total body surface area without significant non-burn related trauma who survived >48 hours post-admission were enrolled. One hundred fifty-nine of these patients were analyzed previously. Methods: Candidate polymorphisms within interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha), cellular differentiation marker 14 (CD14) and toll-like receptor 4 (TLR4) were evaluated by logistic regression analysis for association with increased risk for severe sepsis (sepsis plus organ dysfunction or shock). Results: After adjustment for age, burn size, ethnicity, gender and inhalation injury, alleles at TNF-alpha (308G, p=0.013), TLR4 (+896G, p=0.027), IL-6 (174C, p=0.040) and CD14 (159C, p=0.047) were significantly associated with an increased risk for severe sepsis. Conclusions: Carriage of variant alleles at immune response genes were associated with increased risk for severe sepsis after burn injury.

引用

页码：250 / 255

页数：6

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