NITRIC-OXIDE REGULATES MITOCHONDRIAL RESPIRATION AND CELL FUNCTIONS BY INHIBITING CYTOCHROME-OXIDASE

被引：479

作者：

BROWN, GC

机构：

[1] Department of Biochemistry, University of Cambridge, Cambridge, CB2 1QW, Tennis Court Road

来源：

FEBS LETTERS | 1995年 / 369卷 / 2-3期

关键词：

NITRIC OXIDE; CYTOCHROME C OXIDASE; MITOCHONDRIA; OXYGEN SENSOR; MUSCLE RELAXATION; CYTOKINES;

D O I：

10.1016/0014-5793(95)00763-Y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nitric oxide (NO) reversibly inhibits mitochondrial respiration by competing with oxygen at cytochrome oxidase. Concentrations of NO measured in a range of biological systems are similar to those shown to inhibit cytochrome oxidase and mitochondrial respiration. Inhibition of NO synthesis results in a stimulation of respiration in a number of systems. It is proposed that NO exerts some of its main physiological and pathological effects on cell functions by inhibiting cytochrome oxidase. Further NO may be a physiological regulator of the affinity of mitochondrial respiration for oxygen, enabling mitochondria to act as sensors of oxygen over the physiological range.

引用

页码：136 / 139

页数：4

共 40 条

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