KILLER POLYAMINES

被引：48

作者：

COFFINO, P ^{[1
]}

POZNANSKI, A ^{[1
]}

机构：

[1] UNIV CALIF SAN FRANCISCO,DEPT MED,SAN FRANCISCO,CA 94143

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 1991年 / 45卷 / 01期

关键词：

PROGRAMMED CELL DEATH; DEVELOPMENT; SPERMIDINE; SPERMINE; ACETYLASE; OXIDASE; PEROXIDE;

D O I：

10.1002/jcb.240450112

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mammalian cells can rapidly make large changes in their rate of polyamine biosynthesis in response to mitogenic and trophic signals. However, cultured cells seem to grow adequately as long as they are supplied a steady but unregulated supply of polyamines. This implies that complex and rapid changes in polyamine synthesis serve a function in a special rather than a general biological context. We suggest that the appropriate context in which regulation of polyamines mediates crucial functions is the mammalian embryo and that one function of polyamines is to act as substrate in an oxidative pathway that arbitrates programmed cell death.

引用

页码：54 / 58

页数：5