TIGHTLY REGULATED, DEVELOPMENTALLY SPECIFIC EXPRESSION OF THE FIRST OPEN READING FRAME FROM LINE-1 DURING MOUSE EMBRYOGENESIS

被引：111

作者：

TRELOGAN, SA

MARTIN, SL

机构：

[1] UNIV COLORADO, HLTH SCI CTR, DEPT CELLULAR & STRUCT BIOL, DENVER, CO 80262 USA

[2] UNIV COLORADO, HLTH SCI CTR, PROGRAM MOLEC BIOL, DENVER, CO 80262 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1995年 / 92卷 / 05期

关键词：

GENE EXPRESSION; GERM CELLS; REPETITIVE DNA; RETROTRANSPOSON; STEROIDOGENIC CELLS;

D O I：

10.1073/pnas.92.5.1520

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

LINE-1 (L1) has achieved its status as a middle repetitive DNA family in mammalian genomes by duplicative transposition. Although transposition may occur in any cell type, expression and transposition of a full-length functional element in the germ line are necessary for evolutionarily significant propagation of L1. An immunohistochemical analysis of adult mouse ovaries and mouse postimplantation embryos revealed expression of L1 open reading frame 1 in the germ line as well as in steroidogenic tissues. These results demonstrate that L1 expression is controlled by a tightly regulated temporal and spatial program of events during development and imply that multiple loci of L1 in the mouse genome are active for expression.

引用

页码：1520 / 1524

页数：5

共 30 条

[11]

Kaufman M., 1992, ATLAS MOUSE DEV

[12] HEMOPHILIA-A RESULTING FROM DENOVO INSERTION OF L1 SEQUENCES REPRESENTS A NOVEL MECHANISM FOR MUTATION IN MAN [J].